The Effect of Brotizolam Induced Appetite on Serum Ghrelin Levels in Mice

Objective: Appetite is affected by the metabolic profile, infections and nutritional shape in domestic animals. Regulation of appetite involves many complex physiological processes. Ghrelin well known appetite-enhancing hormone. The also managed lateral hypothalamus. On other hand, ventromedial nucleus most commonly associated with satiety. Brotizolam, member 1,4-benzodiazepines derivative, blocking activity hypothalamus used to increase aim this study was investigate impact brotizolam on serum ghrelin levels, enhancer Methods: A total 16 mice were equally assigned two groups as control (0.9% NaCl, IP) (2 μg/kg, IP). Blood samples collected 30 min after administration both groups. Serum levels determined enzyme linked immunoassay. Results: There a significance differences between (P<0.001). results showed that increased levels. Conclusion: which suppresses satiety, can activate activation levels.In addition, may be an endocrine marker appetite.